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Literature summary for 6.4.1.1 extracted from

  • Attwood, P.V.
    The structure and the mechanism of action of pyruvate carboxylase (1995), Int. J. Biochem. Cell Biol., 27, 231-249.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
acetyl-CoA
-
Gallus gallus
acetyl-CoA
-
Aspergillus nidulans
acetyl-CoA highly dependent on vertebrata
acetyl-CoA quite active in absence of acetyl-CoA Saccharomyces cerevisiae

General Stability

General Stability Organism
acetyl-CoA stabilizes quarternary structure of the enzyme Gallus gallus
acetyl-CoA stabilizes quarternary structure of the enzyme Aspergillus nidulans

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
Gallus gallus
Mn2+ each subunit contains one tightly bound metal ion, predominantly Mn2+, or mixtures of Mn2+ and Mg2+ vertebrata
Zinc each subunit contains one tightly bound Zn2+ Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-
Gallus gallus
-
-
-
Pseudomonas citronellolis
-
-
-
Saccharomyces cerevisiae
-
-
-
vertebrata
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + pyruvate + HCO3- + H+ = ADP + phosphate + oxaloacetate mechanism, overview vertebrata

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate + HCO3-
-
Gallus gallus ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Saccharomyces cerevisiae ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Aspergillus nidulans ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Pseudomonas citronellolis ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
vertebrata ADP + phosphate + oxaloacetate
-
?