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Literature summary for 6.4.1.1 extracted from

  • Charles, A.M.; Butler, B.J.; Willer, D.
    Pyruvate carboxylase from the facultative chemolithothrophs Thiobacillus A2 and Thiobacillus novellus (1980), FEMS Microbiol. Lett., 8, 9-12.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
acetyl-CoA
-
Starkeya novella
acetyl-CoA powerful activator Thiobacillus sp.

Inhibitors

Inhibitors Comment Organism Structure
additional information inhibition with physiological amounts of amino acids or dicarboxylate is not obtained Starkeya novella
additional information inhibition with physiological amounts of amino acids or dicarboxylate is not obtained Thiobacillus sp.

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
Starkeya novella
K+ required Thiobacillus sp.
Mg2+ required Starkeya novella
Mg2+ required Thiobacillus sp.
Mg2+ Km: 0.44 mM Starkeya novella
Mg2+ Km: 0.36 mM Thiobacillus sp.

Organism

Organism UniProt Comment Textmining
Starkeya novella
-
-
-
Thiobacillus sp.
-
A2
-
Thiobacillus sp. A2
-
A2
-

Purification (Commentary)

Purification (Comment) Organism
-
Thiobacillus sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Thiobacillus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate + HCO3-
-
Starkeya novella ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Thiobacillus sp. ADP + phosphate + oxaloacetate
-
?
ATP + pyruvate + HCO3-
-
Thiobacillus sp. A2 ADP + phosphate + oxaloacetate
-
?