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Literature summary for 6.3.5.6 extracted from
- New WS9326A congeners from Streptomyces sp. 9078 inhibiting Brugia malayi asparaginyl-tRNA synthetase (2012), Org. Lett., 14, 4946-4949.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| WS9326A | little inhibitory activity at 0.1 mM | Brugia malayi | |
| WS9326C | little inhibitory activity at 0.1 mM | Brugia malayi | |
| WS9326D | specific inhibitor, moderate inhibition | Brugia malayi | |
| WS9326E | moderate inhibition | Brugia malayi |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brugia malayi | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AsnRS | - |
Brugia malayi |
| Asparaginyl-tRNA synthetase | - |
Brugia malayi |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
pH and temperature not specified in the publication | Brugia malayi | WS9326D | |
| 0.075 | - |
pH and temperature not specified in the publication | Brugia malayi | WS9326E |
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