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Literature summary for 6.3.5.6 extracted from

  • Yu, Z.; Vodanovic-Jankovic, S.; Ledeboer, N.; Huang, S.X.; Rajski, S.R.; Kron, M.; Shen, B.
    Tirandamycins from Streptomyces sp. 17944 inhibiting the parasite Brugia malayi asparagine tRNA synthetase (2011), Org. Lett., 13, 2034-2037.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.5.6

Application

Application Comment Organism
biotechnology inhibitor represents a lead scaffold to discover and develop antifilarial drugs Brugia malayi

Inhibitors

Inhibitors Comment Organism Structure
(3Z)-3-[(2E,4E)-1-hydroxy-6-[(2S,4R)-2-(hydroxymethyl)-1,7-dimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]dec-8-yl]-4-methylhepta-2,4-dien-1-ylidene]pyrrolidine-2,4-dione
-
 Brugia malayi

Organism

Organism UniProt Comment Textmining
Brugia malayi
-
-
-

Synonyms

Synonyms Comment Organism
AsnRS
-
 Brugia malayi
Asparaginyl-tRNA synthetase
-
 Brugia malayi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.03
-
 pH and temperature not specified in the publication, selectively inhibits the Brugia malayi AsnRS and efficiently kills the adult Brugia malayi parasite Brugia malayi (3Z)-3-[(2E,4E)-1-hydroxy-6-[(2S,4R)-2-(hydroxymethyl)-1,7-dimethyl-5-oxo-3,9,10-trioxatricyclo[4.3.1.02,4]dec-8-yl]-4-methylhepta-2,4-dien-1-ylidene]pyrrolidine-2,4-dione