Literature summary for 6.3.5.5 extracted from

Guy, H.I.; Bouvier, A.; Evans, D.R.
The smallest carbamoyl-phosphate synthetase. A single catalytic subdomain catalyzes all three partial reactions (1997), J. Biol. Chem., 14; 272, 29255-29262.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Escherichia coli

Protein Variants

Protein Variants	Comment	Organism
additional information	smaller recombinant proteins in which the subdomains A1, A2, A3, B1, B2, or B3 of the synthetase subunit are deleted, show that subdomains A1 and B1 are attenuation domains which suppress the intrinsically high activity and are required for the physical association with the glutaminase subunit	Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
40000	-	1 * 40000, glutaminase subunit, + 1 * 120000, synthase subunit. The synthase subunit consists of two homologous domains, CPS.A and CPS.B, which catalyze the two different ATP-dependent partial reactions involved in carbamoyl-phosphate synthesis	Escherichia coli
120000	-	1 * 40000, glutaminase subunit, + 1 * 120000, synthase subunit. The synthase subunit consists of two homologous domains, CPS.A and CPS.B, which catalyze the two different ATP-dependent partial reactions involved in carbamoyl-phosphate synthesis	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 ATP + L-Gln + HCO3-	-	Escherichia coli	2 ADP + phosphate + L-Glu + carbamoyl phosphate	-	?

Subunits

Subunits	Comment	Organism
dimer	1 * 40000, glutaminase subunit, + 1 * 120000, synthase subunit. The synthase subunit consists of two homologous domains, CPS.A and CPS.B, which catalyze the two different ATP-dependent partial reactions involved in carbamoyl-phosphate synthesis	Escherichia coli

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Release 2023.1 (January 2023)