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Literature summary for 6.3.5.2 extracted from
- The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine (1995), J. Biol. Chem., 270, 23450-23455.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acivicin | selectively abolishes glutaminase activity and Gln-dependent synthetase activity. No effect on NH4+-dependent synthetase activity | Homo sapiens |  |
| diphosphate | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | key enzyme in the de novo synthesis of guanine nucleotides | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + XMP + NH4+ | - |
Homo sapiens | AMP + diphosphate + GMP | - |
? | |
| additional information | key enzyme in the de novo synthesis of guanine nucleotides | Homo sapiens | ? | - |
? | |
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