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Literature summary for 6.3.5.2 extracted from

  • Spector, T.; Miller, R.L.; Fyfe, J.A.; Krenitsky, T.A.
    GMP synthetase from Escherichia coli B-96. Interactions with substrate analogs (1974), Biochim. Biophys. Acta, 370, 585-591.
    View publication on PubMed
Search for more literature for 6.3.5.2

Inhibitors

Inhibitors Comment Organism Structure
1-Ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine 5'-phosphate
-
 Escherichia coli
1-Ribosyl-4-hydroxy-6-aminopyrazolo[3,4-d]pyrimidine 5'-phosphate
-
 Escherichia coli
6-ThioGMP
-
 Escherichia coli
6-thioXMP
-
 Escherichia coli
8-azaGMP
-
 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.058
-
 XMP
-
 Escherichia coli
0.35
-
 8-azaXMP
-
 Escherichia coli
0.42
-
 6-thioXMP
-
 Escherichia coli
2
-
 1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine 5-phosphate
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli B96
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine 5-phosphate
-
 Escherichia coli AMP + phosphate + 1-ribosyl-4-hydroxy-6-aminopyrazolo[3,4-d]pyrimidine 5'-phosphate
-
 ?
ATP + 1-ribosyl-4,6-dihydroxypyrazolo[3,4-d]-pyrimidine 5-phosphate
-
 Escherichia coli B96 AMP + phosphate + 1-ribosyl-4-hydroxy-6-aminopyrazolo[3,4-d]pyrimidine 5'-phosphate
-
 ?
ATP + 6-thioXMP + NH4+
-
 Escherichia coli AMP + phosphate + 6-thioGMP
-
 ?
ATP + 6-thioXMP + NH4+
-
 Escherichia coli B96 AMP + phosphate + 6-thioGMP
-
 ?
ATP + 8-azaXMP + NH4+
-
 Escherichia coli AMP + phosphate + 8-azaGMP
-
 ?
ATP + 8-azaXMP + NH4+
-
 Escherichia coli B96 AMP + phosphate + 8-azaGMP
-
 ?
ATP + XMP + NH4+
-
 Escherichia coli AMP + diphosphate + GMP
-
 ?
ATP + XMP + NH4+
-
 Escherichia coli B96 AMP + diphosphate + GMP
-
 ?