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Literature summary for 6.3.5.1 extracted from

  • Lin, H.; Kwan, A.L.; Dutcher, S.K.
    Synthesizing and salvaging NAD: lessons learned from Chlamydomonas reinhardtii (2010), PLoS Genet., 6, e1001105.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
S740I Chlamydomonas cells bearing a NAD+ synthase mutation have a defective NAD+ de novo synthesis pathway. Mutant cells show longer vegitative life span than wild-type cells. Up-regulation of a sirtuin gene is linked to the extended life span in the mutant strain Chlamydomonas reinhardtii
S740I mutant fails to grow on Sager and Granick rich medium without nicotinamide or Sager and Garnick medium supplemented with 3-acetylpyridine. Mutants grows well on media supplied with either nicotinamide or NMN. Addition of nicotinic acid shows very weak rescue of the nic- mutant phenotype. Addition of 3-hydroxyanthranilate cannot rescue the growth defect. Sirtuin SRT2 levels are 2- to 2.5fold increased in the mutant with concomitant increase in reproductive capactiy Chlamydomonas reinhardtii

Organism

Organism UniProt Comment Textmining
Chlamydomonas reinhardtii C4PG67
-
-

Synonyms

Synonyms Comment Organism
NAD+ synthase
-
 Chlamydomonas reinhardtii
nic13
-
 Chlamydomonas reinhardtii

General Information

General Information Comment Organism
malfunction a homolog of the human SIRT6-like gene, SRT2, is upregulated in the NAD+ synthase mutant, which shows a longer vegetative life span than wild-type cells Chlamydomonas reinhardtii