Literature summary for 6.3.4.6 extracted from

Navarathna, D.; Das, A.; Morschhauser, J.; Nickerson, K.; Roberts, D.
Dur3 is the major urea transporter in Candida albicans and is co-regulated with the urea amidolyase Dur1,2 (2011), Microbiology, 157, 270-279.

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Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-

Expression

Organism	Comment	Expression
Candida albicans	DUR1,2 and urea transporter DUR3 expression is strongly induced by urea, whereas the other putative transporter genes are induced less than twofold. Urea induction of DUR1,2 is reduced in a transcription factor gat1D mutant, strongly reduced in a transcription factor gln3D mutant, and abolished in a gat1D gln3D double mutant. Expression of DUR1,2 and DUR3 is higher in the GP basal media than in YPD medium. Addition of proline or glutamine at 10 mM in the presence of urea significantly repressed expression relative to urea alone. Urea induction of DUR3 is not dependent upon DUR1,2 expression	up

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Release 2023.1 (January 2023)