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Literature summary for 6.3.4.5 extracted from

  • Prima, V.; Wang, A.; Molina, G.; Wang, K.K.; Svetlov, S.I.
    Inhibition of LPS toxicity by hepatic argininosuccinate synthase (ASS): Novel roles for ASS in innate immune responses to bacterial infection (2011), Int. Immunopharmacol., 11, 1180-1188.
    View publication on PubMed
Search for more literature for 6.3.4.5

Activating Compound

Activating Compound Comment Organism Structure
lipopolysaccharide argininosuccinate synthase accumulates in circulation within 1 h after treatment with both lipopolysaccharide alone and hepatotoxic combination of lipopolysaccharide and D-Galactosamine. Enzyme physically binds to lipopolysaccharide Mus musculus
lipopolysaccharide argininosuccinate synthase accumulates in circulation within 1 h after treatment with both lipopolysaccharide alone and hepatotoxic combination of lipopolysaccharide and D-Galactosamine. Enzyme physically binds to lipopolysaccharide Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus
expression in Escherichia coli Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47000
-
 x * 47000, calculated for His-tagged recombinant protein Mus musculus
47000
-
 x * 47000, calculated for His-tagged recombinant protein Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00966
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
 Mus musculus
-
liver
-
 Mus musculus
-
serum argininosuccinate synthase accumulates in circulation within 1 h after treatment with both lipopolysaccharide alone and hepatotoxic combination of lipopolysaccharide and D-Galactosamine Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 47000, calculated for His-tagged recombinant protein Mus musculus
? x * 47000, calculated for His-tagged recombinant protein Homo sapiens

General Information

General Information Comment Organism
physiological function recombinant argininosuccinate synthase reduces lipolysaccharide cytotoxicity, TNF-alpha production, and increases cell viability in cultured mouse macrophages, even when added one h following lipopolysaccharide challenge. Intraperitoneal injection of recombinant argininosuccinate synthase at 5 mg/kg after treatment with a high dose of lipopolysaccharide remarkably increases survival of rodents, with a concomitant decrease of sepsis markers TNF-alpha, C-reactive protein, and lactate dehydrogenase levels in blood Mus musculus