Literature summary for 6.3.4.5 extracted from

Nicholson, L.J.; Smith, P.R.; Hiller, L.; Szlosarek, P.W.; Kimberley, C.; Sehouli, J.; Koensgen, D.; Mustea, A.; Schmid, P.; Crook, T.
Epigenetic silencing of argininosuccinate synthetase confers resistance to platinum-induced cell death but collateral sensitivity to arginine auxotrophy in ovarian cancer (2009), Int. J. Cancer, 125, 1454-1463.

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Application

Application	Comment	Organism
medicine	potential novel therapeutic strategies for ovarian cancer	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
ovary cancer cell line	-	Homo sapiens	-
OVCA-433 cell	-	Homo sapiens	-
SKOV-3 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
arininosuccinate synthetase	-	Homo sapiens
ASS1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	downregulation of enzyme expression is associated with the development of platinum resistance to platinum-based drugs	additional information

General Information

General Information	Comment	Organism
physiological function	rate-limiting enzyme in the biosynthesis of arginine	Homo sapiens

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Release 2023.1 (January 2023)