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Literature summary for 6.3.4.5 extracted from
- Identification of a liver-specific cAMP response element in the human argininosuccinate synthetase gene (2008), Biochem. Biophys. Res. Commun., 377, 257-261.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | CRE-1 is the cis-element responsible for liver-specific cAMP induction of the human ASS gene | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | HNF4 mutations influence enzyme expression activity | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-citrulline + L-aspartate | Homo sapiens | the key enzyme in the urea cycle participates in many metabolic processes including arginine biosynthesis and the citrulline-nitric oxide cycle | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
| additional information | Homo sapiens | factors like diets, hormones and pro-inflammatory stimuli regulate ASS gene expression primarily at the transcription level | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Huh-7 cell | a human hepatoma cell line | Homo sapiens | - |
| liver | - |
Homo sapiens | - |
| RPMI-2650 cell | a human epithelium cell line | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-citrulline + L-aspartate | - |
Homo sapiens | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
| ATP + L-citrulline + L-aspartate | the key enzyme in the urea cycle participates in many metabolic processes including arginine biosynthesis and the citrulline-nitric oxide cycle | Homo sapiens | AMP + diphosphate + 2-(Nomega-L-arginino)succinate | - |
? | |
| additional information | factors like diets, hormones and pro-inflammatory stimuli regulate ASS gene expression primarily at the transcription level | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Argininosuccinate synthetase | - |
Homo sapiens |
| ASS | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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