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Literature summary for 6.3.4.5 extracted from

  • Kawahara, K.; Gotoh, T.; Oyadomari, S.; Kajizono, M.; Kuniyasu, A.; Ohsawa, K.; Imai, Y.; Kohsaka, S.; Nakayama, H.; Mori, M.
    Co-induction of argininosuccinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells (2001), Mol. Brain Res., 90, 165-173.
    View publication on PubMed
Search for more literature for 6.3.4.5

Activating Compound

Activating Compound Comment Organism Structure
additional information AS mRNA is 4-6fold induced by Escherichia coli lipopolysaccharide and mouse interferon-gamma, kinetics of induction Mus musculus
additional information AS mRNA is induced by Escherichia coli lipopolysaccharide and mouse interferon-gamma Rattus norvegicus

Application

Application Comment Organism
medicine citrulline-arginine recycling enzyme, intervention in the supply of arginine may represent a new therapeutic approach to the treatment of NO-mediated neurodegenerative damage in the brain Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
46000
-
 x * 46000, immunoblot analysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus urea cycle, enzyme of citrulline-arginine recycling, which is important for high output production of NO in activated microglial cells, inducible enzyme ?
-
 ?
additional information Rattus norvegicus urea cycle, enzyme of citrulline-arginine recycling, which is important for high output production of NO in activated microglial cells, inducible enzyme ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
 Wistar rats, 2 days old
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information urea cycle, enzyme of citrulline-arginine recycling, which is important for high output production of NO in activated microglial cells, inducible enzyme Mus musculus ?
-
 ?
additional information urea cycle, enzyme of citrulline-arginine recycling, which is important for high output production of NO in activated microglial cells, inducible enzyme Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
? x * 46000, immunoblot analysis Mus musculus

Synonyms

Synonyms Comment Organism
Argininosuccinate synthetase
-
 Mus musculus
Argininosuccinate synthetase
-
 Rattus norvegicus
AS
-
 Mus musculus
AS
-
 Rattus norvegicus