Literature summary for 6.3.4.3 extracted from

Mejillano, M.R.; Jahansouz, H.; Matsunaga, T.O.; Kenyon, G.L.; Himes, R.H.
Formation and utilization of formyl phosphate by N10-formyltetrahydrofolate synthetase: evidence for formyl phosphate as an intermediate in the reaction (1989), Biochemistry, 28, 5136-5145.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
K+	stimulates formate kinase reaction, Km: 8.7 mM	Saccharomyces cerevisiae
K+	stimulates formate kinase reaction, Km: 8.7 mM	Clostridium cylindrosporum
Mg2+	stimulates formate kinase reaction, Km: 0.88 mM	Saccharomyces cerevisiae
Mg2+	stimulates formate kinase reaction, Km: 0.88 mM	Clostridium cylindrosporum

Organism

Organism	UniProt	Comment	Textmining
Clostridium cylindrosporum	-	-	-
Saccharomyces cerevisiae	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate	sequential mechanism, formyl phosphate is an intermediate	Saccharomyces cerevisiae	a
ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate	sequential mechanism, formyl phosphate is an intermediate	Clostridium cylindrosporum	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + formate	formate kinase reaction, sequential random bi bi mechanism	Saccharomyces cerevisiae	ADP + HCOOPO32-	-	?
ATP + formate	formate kinase reaction, sequential random bi bi mechanism	Clostridium cylindrosporum	ADP + HCOOPO32-	-	?
ATP + formate + tetrahydrofolate	-	Saccharomyces cerevisiae	ADP + phosphate + 10-formyltetrahydrofolate	-	?
ATP + formate + tetrahydrofolate	-	Clostridium cylindrosporum	ADP + phosphate + 10-formyltetrahydrofolate	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Saccharomyces cerevisiae
additional information	-	additional information	-	Clostridium cylindrosporum

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Release 2023.1 (January 2023)