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Literature summary for 6.3.4.21 extracted from
- Enhancement of succinate production by metabolically engineered Escherichia coli with co-expression of nicotinic acid phosphoribosyltransferase and pyruvate carboxylase (2013), Appl. Microbiol. Biotechnol., 97, 6739-6747.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strains BA002, BA014, BA015, and BA016 | Escherichia coli |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 45000 | - |
x * 45000, SDS-PAGE | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | Escherichia coli | - |
beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P18133 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.7 | - |
recombinant enzyme from Escherichia coli strain BA002, pH and temperature not specified in the publication | Escherichia coli |
| 1.01 | - |
recombinant enzyme from Escherichia coli strain BA015, pH and temperature not specified in the publication | Escherichia coli |
| 10.54 | - |
recombinant enzyme from Escherichia coli strain BA014, pH and temperature not specified in the publication | Escherichia coli |
| 18.74 | - |
recombinant enzyme from Escherichia coli strain BA016, pH and temperature not specified in the publication | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O | - |
Escherichia coli | beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 45000, SDS-PAGE | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| EC 2.4.2.11 | formerly | Escherichia coli |
| NAPRTase | - |
Escherichia coli |
| nicotinic acid phosphoribosyltransferase | - |
Escherichia coli |
| pncB | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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