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Literature summary for 6.3.4.2 extracted from

  • Goto, M.; Omi, R.; Nakagawa, N.; Miyahara, I.; Hirotsu, K.
    Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites (2004), Structure, 12, 1413-1423.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structures of Thermus thermophilus HB8 CTP synthetase as a tetramer in its native form, CTP synthetase as complex with 3 SO42- and CTP synthetase as a complex with glutamine. Crystallization at 20 °C using vapor-diffusion method. The space group is I222 with cell dimensions of a = 90.4 A, b = 117.1 A and c = 142.3 A Thermus thermophilus HB8

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UTP + NH4+ Thermus thermophilus HB8 last step in CTP biosynthesis ADP + phosphate + CTP
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Organism

Organism UniProt Comment Textmining
Thermus thermophilus HB8 Q5SIA8
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UTP + NH4+
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Thermus thermophilus HB8 ADP + phosphate + CTP
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ATP + UTP + NH4+ last step in CTP biosynthesis Thermus thermophilus HB8 ADP + phosphate + CTP
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Synonyms

Synonyms Comment Organism
CTP synthetase
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Thermus thermophilus HB8