Application | Comment | Organism |
---|---|---|
medicine | human hepatocellular carcinoma cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues. The expression of CPS1 in human hepatocellular carcinoma cells is restored with demethylation agent, 5-azacytidine. Two CpG dinucleotides, located near the transcription start site, and a CpG-rich region in the first intron are hypermethylated in human hepatocellular carcinoma cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P31327 | isoform CPS1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | cultured human primary hepatocytes, express CPS1 at abundant levels | Homo sapiens | - |
liver | - |
Homo sapiens | - |
additional information | hepatocellular carcinoma cell lines Huh7, Huh7.5 and LH86 lack expression of CPS1. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues | Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | human hepatocellular carcinoma cells do not express CPS1, whereas cultured human primary hepatocytes express abundant levels. CPS1 is silenced or down-regulated in liver tumor tissues compared with the matched noncancerous tissues. The expression of CPS1 in human hepatocellular carcinoma cells is restored with demethylation agent, 5-azacytidine. Two CpG dinucleotides, located near the transcription start site, and a CpG-rich region in the first intron are hypermethylated in human hepatocellular carcinoma cells | down |