Literature summary for 6.3.4.16 extracted from

Moore, P.E.; Ryckman, K.K.; Williams, S.M.; Patel, N.; Summar, M.L.; Sheller, J.R.
Genetic variants of GSNOR and ADRB2 influence response to albuterol in African-American children with severe asthma (2009), Pediatr. Pulmonol., 44, 649-654.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene CPS1, located on chromosome 2, genotyping, overview	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P31327	African American children	-

Synonyms

Synonyms	Comment	Organism
carbamoyl phosphate synthetase-1	-	Homo sapiens
CPS1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	single nucleotide polymorphisms in the gene encoding CPS1 are involved, together with mutations in other genes encoding for other enzymes, in the development of severe asthma by African American children, which show a higher rate of this disease compared to other ethnics, overview. A combination of four single nucleotide polymorphisms (SNPs) within GSNOR, adrenergic receptor beta 2, and carbamoyl phosphate synthetase-1 give a 70% predictive value for lack of response to therapy	Homo sapiens

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Release 2023.1 (January 2023)