Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | the inhibitory effect of free Ca2+ is weak. The calcium inhibition can be accounted for primarily by competitive interaction of CaATP2- at the second MgATP2- binding site. With 1 mM free Mg2+ and 5 mM MgATP2-, half-maximal inhibition is obtained with 0.2 mM CaATP2- | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
ATP | - |
Rattus norvegicus | |
1.35 | - |
ATP | - |
Rattus norvegicus | |
2.2 | - |
ATP | - |
Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for CoATP2-: 2.2 mM | Rattus norvegicus | |
Mg2+ | divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for MgATP2-: 1.35 mM | Rattus norvegicus | |
Mn2+ | divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for MnATP2-: 1.0 mM | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 ATP + NH4+ + HCO3- | ATP in form of MnATP2- | Rattus norvegicus | 2 ADP + phosphate + carbamoyl phosphate | - |
? | |
2 ATP + NH4+ + HCO3- | ATP in form of MgATP2- | Rattus norvegicus | 2 ADP + phosphate + carbamoyl phosphate | - |
? | |
2 ATP + NH4+ + HCO3- | ATP in form of CoATP2- | Rattus norvegicus | 2 ADP + phosphate + carbamoyl phosphate | - |
? | |
ATP + NH4+ + CO2 + H2O | - |
Rattus norvegicus | ADP + phosphate + carbamoylphosphate | - |
? |