Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.4.16 extracted from

  • Cerdan, S.; Lusty, C.J.; Davis, K.N.; Jacobson, J.A.; Williamson, J.R.
    Role of calcium as an inhibitor of rat liver carbamylphosphate synthetase I (1984), J. Biol. Chem., 259, 323-331.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ca2+ the inhibitory effect of free Ca2+ is weak. The calcium inhibition can be accounted for primarily by competitive interaction of CaATP2- at the second MgATP2- binding site. With 1 mM free Mg2+ and 5 mM MgATP2-, half-maximal inhibition is obtained with 0.2 mM CaATP2- Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
ATP
-
Rattus norvegicus
1.35
-
ATP
-
Rattus norvegicus
2.2
-
ATP
-
Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for CoATP2-: 2.2 mM Rattus norvegicus
Mg2+ divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for MgATP2-: 1.35 mM Rattus norvegicus
Mn2+ divalent metal ion required, Mg2+, Mn2+ or Co2+, Km for MnATP2-: 1.0 mM Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + NH4+ + HCO3- ATP in form of MnATP2- Rattus norvegicus 2 ADP + phosphate + carbamoyl phosphate
-
?
2 ATP + NH4+ + HCO3- ATP in form of MgATP2- Rattus norvegicus 2 ADP + phosphate + carbamoyl phosphate
-
?
2 ATP + NH4+ + HCO3- ATP in form of CoATP2- Rattus norvegicus 2 ADP + phosphate + carbamoyl phosphate
-
?
ATP + NH4+ + CO2 + H2O
-
Rattus norvegicus ADP + phosphate + carbamoylphosphate
-
?