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Literature summary for 6.3.4.15 extracted from

  • Zempleni, J.; Wijeratne, S.S.; Hassan, Y.I.
    Biotin (2009), Biofactors, 35, 36-46.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.4.15

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + biotin + apo-[acetyl-CoA carboxylase 1] Homo sapiens cytoplasmic acetyl-CoA carboxylase isozyme AMP + diphosphate + acetyl-CoA carboxylase 1
-
 ?
ATP + biotin + apo-[acetyl-CoA carboxylase 2] Homo sapiens mitochondrial acetyl-CoA carboxylase isozyme AMP + diphosphate + acetyl-CoA carboxylase 2
-
 ?
additional information Homo sapiens holocarboxylase synthetase catalyzes the attachment of biotin to the epsilon-amino group of a specific lysine residue in apocarboxylases, biotinylation of biotin-dependent carboxylases requires ATP and proceeds in the following two steps ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + biotin + apo-[acetyl-CoA carboxylase 1] cytoplasmic acetyl-CoA carboxylase isozyme Homo sapiens AMP + diphosphate + acetyl-CoA carboxylase 1
-
 ?
ATP + biotin + apo-[acetyl-CoA carboxylase 2] mitochondrial acetyl-CoA carboxylase isozyme Homo sapiens AMP + diphosphate + acetyl-CoA carboxylase 2
-
 ?
ATP + biotin + apo-[propionyl-CoA carboxylase]
-
 Homo sapiens AMP + diphosphate + propionyl-CoA carboxylase
-
 ?
additional information holocarboxylase synthetase catalyzes the attachment of biotin to the epsilon-amino group of a specific lysine residue in apocarboxylases, biotinylation of biotin-dependent carboxylases requires ATP and proceeds in the following two steps Homo sapiens ?
-
 ?
additional information the 4'-hydroxyazobenzene-2-carboxylic acid dye assay can be used to quantify biotin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HCS
-
 Homo sapiens
Holocarboxylase synthetase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction biotin deficiency, e.g. occuring in patients with BTD deficiency, in severely malnourished children in developing countries, and in individuals consuming large amounts of raw egg white which contains the protein avidin, has adverse effects on cellular and humoral immune functions, and it can lead to candida dermatitis and presented with absent delayed-hypersensitivity skin-tests responses, IgA deficiency, and subnormal percentages of T-lymphocytes in peripheral blood, overview Homo sapiens
metabolism the enzyme is involved in the biotin metabolism, detailed overview Homo sapiens