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Literature summary for 6.3.3.2 extracted from
- Regulation of de novo purine biosynthesis by methenyltetrahydrofolate synthetase in neuroblastoma (2006), J. Biol. Chem., 281, 4215-4221.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 10-formylfolic acid | - |
Homo sapiens |  |
| folic acid | - |
Homo sapiens | |
| folic acid pentaglutamate | - |
Homo sapiens | |
| folic acid triglutamate | - |
Homo sapiens | |
| [6R,S]-10-formyltetrahydrofolate triglutamate | - |
Homo sapiens | |
| [6R,S]-10-formyltetrahydrohomofolate | - |
Homo sapiens | |
| [6R,S]-10-formyltetrahydropteroate | - |
Homo sapiens | |
| [6R,S]-5-formyltetrahydrohomofolate | - |
Homo sapiens | |
| [6R]-10-formyltetrahydrofolate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| neuroblastoma cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5-formyltetrahydrofolate | - |
Homo sapiens | ADP + 5,10-methenyltetrahydrofolate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Methenyltetrahydrofolate synthetase | - |
Homo sapiens |
| MTHFS | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
[6R,S]-10-formyltetrahydrofolate triglutamate | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
| 0.0001 | - |
folic acid pentaglutamate | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
| 0.00015 | - |
[6R]-10-formyltetrahydrofolate | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
| 0.0002 | - |
[6R,S]-10-formyltetrahydrohomofolate | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
| 0.0007 | - |
[6R,S]-5-formyltetrahydrohomofolate | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
| 0.0017 | - |
folic acid triglutamate | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
| 0.005 | - |
[6R,S]-10-formyltetrahydropteroate | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
| 0.013 | - |
10-formylfolic acid | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
| 0.058 | - |
folic acid | at 37°C in 100 mM MES, pH 6.0 | Homo sapiens | |
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