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Literature summary for 6.3.3.2 extracted from
- Ontogeny of hepatic enzymes involved in serine- and folate-dependent one-carbon metabolism in rabbits (2001), Am. J. Physiol., 280, G873-G878.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5-formyltetrahydrofolate | Oryctolagus cuniculus | enzyme plays a central role in the regulation of folate-dependent, one-carbon metabolism | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | increase during development | Oryctolagus cuniculus | - |
| liver | low activity in fetus, maximum at age 3 weeks, and again decline to moderate adult level | Oryctolagus cuniculus | - |
| placenta | low activity | Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.00006 | - |
placenta | Oryctolagus cuniculus |
| 0.00026 | - |
postweaning, brain | Oryctolagus cuniculus |
| 0.00032 | - |
kidney | Oryctolagus cuniculus |
| 0.00036 | - |
fetal liver | Oryctolagus cuniculus |
| 0.0011 | - |
adult liver | Oryctolagus cuniculus |
| 0.0015 | - |
3 weeks old liver | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 5-formyltetrahydrofolate | - |
Oryctolagus cuniculus | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
? | |
| ATP + 5-formyltetrahydrofolate | enzyme plays a central role in the regulation of folate-dependent, one-carbon metabolism | Oryctolagus cuniculus | ADP + phosphate + 5,10-methenyltetrahydrofolate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-FCL | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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