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Literature summary for 6.3.3.2 extracted from

  • Greenberg, D.M.; Wynston, L.K.; Nagabhushanam, A.
    Further studies on N5-formyltetrahydrofolic acid cyclodehydrase (1965), Biochemistry, 4, 1872-1878.
No PubMed abstract available
Search for more literature for 6.3.3.2

Inhibitors

Inhibitors Comment Organism Structure
AgNO3
-
 Ovis aries
NEM
-
 Ovis aries
o-Iodosobenzoate
-
 Ovis aries
p-mercuribenzoate
-
 Ovis aries

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.14
-
 5-formyltetrahydrofolate
-
 Ovis aries
0.45
-
 ATP
-
 Ovis aries

Organism

Organism UniProt Comment Textmining
Ovis aries
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Ovis aries

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Ovis aries
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Ovis aries

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 5-formyltetrahydrofolate
-
 Ovis aries ADP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
 5-10 min, stable Ovis aries
50
-
 5 min, 23% loss of activity, 10 min, 50% loss of activity Ovis aries
55
-
 5 min, 82% loss of activity, 10 min, 91% loss of activity Ovis aries

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.8
-
-
 Ovis aries

pH Range

pH Minimum pH Maximum Comment Organism
4 6 4.0: about 50% of maximal activity, 6.0: about 60% of maximal activity Ovis aries