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Literature summary for 6.3.2.8 extracted from
- Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway (2011), ChemBioChem, 12, 1171-1173.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| feglymycin | isolated from Streptomyces sp. DSM 11171, 13-mer peptide, noncompetitive inhibition, the inhibition is fully reversible after dilution | Escherichia coli |  |
| feglymycin | isolated from Streptomyces sp. DSM 11171, 13-mer peptide, noncompetitive inhibition, the inhibition is fully reversible after dilution | Staphylococcus aureus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + UDP-N-acetylmuramate + L-alanine | Staphylococcus aureus | - |
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine | - |
? | |
| ATP + UDP-N-acetylmuramate + L-alanine | Escherichia coli | - |
ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
gene murC | - |
| Staphylococcus aureus | - |
gene murC | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + UDP-N-acetylmuramate + L-alanine | - |
Staphylococcus aureus | ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine | - |
? | |
| ATP + UDP-N-acetylmuramate + L-alanine | - |
Escherichia coli | ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MurC | - |
Staphylococcus aureus |
| MurC | - |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Staphylococcus aureus |
| 25 | - |
assay at | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Staphylococcus aureus | |
| ATP | - |
Escherichia coli | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0003 | - |
feglymycin | pH not specified in the publication, 25°C | Escherichia coli | |
| 0.001 | - |
feglymycin | pH not specified in the publication, 25°C | Staphylococcus aureus | |
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