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Literature summary for 6.3.2.8 extracted from

  • Deng, G.; Gu, R.F.; Marmor, S.; Fisher, S.L.; Jahic, H.; Sanyal, G.
    Development of an LC-MS based enzyme activity assay for MurC: application to evaluation of inhibitors and kinetic analysis (2004), J. Pharm. Biomed. Anal., 35, 817-828.
    View publication on PubMed
Search for more literature for 6.3.2.8

Inhibitors

Inhibitors Comment Organism Structure
ADP
-
 Escherichia coli
beta-gamma-methyleneadenosine 5'-triphosphate
-
 Escherichia coli
UDP-2-(acetylamino)-4-O-[[(2-carboxypropyl)(hydroxy)phosphoryl]methyl]-2-deoxy-alpha-D-glucopyranose
-
 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0229
-
 L-alanine
-
 Escherichia coli
0.0343
-
 UDP-N-acetylmuramate
-
 Escherichia coli
0.0638
-
 ATP
-
 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Escherichia coli 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + UDP-N-acetylmuramate + L-alanine Escherichia coli
-
 ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + UDP-N-acetylmuramate + L-alanine
-
 Escherichia coli ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine
-
 ?

Synonyms

Synonyms Comment Organism
MurC
-
 Escherichia coli
UNAM:Ala ligase
-
 Escherichia coli

pH Range

pH Minimum pH Maximum Comment Organism
5.5 10.5
-
 Escherichia coli