Literature summary for 6.3.2.8 extracted from

Liger, D.; Blanot, D.; van Heijenoort, J.
Effect of various alanine analogues on the L-alanine-adding enzyme from Escherichia coli (1991), FEMS Microbiol. Lett., 80, 111-116.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3,3,3-Trifluoro-DL-Ala	-	Escherichia coli
3,3-Difluoro-L-Ala	-	Escherichia coli
3-chloro-L-Ala	-	Escherichia coli
3-Cyano-L-Ala	-	Escherichia coli
3-Fluoro-L-Ala	-	Escherichia coli
Gly	-	Escherichia coli
L-2-aminobutyrate	-	Escherichia coli
L-Cys	weak	Escherichia coli
L-lactate	-	Escherichia coli
L-propargylglycine	-	Escherichia coli
L-Ser	-	Escherichia coli
L-Vinylglycine	-	Escherichia coli
N-Methyl-L-Ala	weak	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	K12HfrH	-
Escherichia coli K12HfrH	-	K12HfrH	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + UDP-N-acetylmuramate + L-Ala	-	Escherichia coli	ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala	-	?
ATP + UDP-N-acetylmuramate + L-Ala	-	Escherichia coli K12HfrH	ADP + phosphate + UDP-N-acetylmuramoyl-L-Ala	-	?

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Release 2023.1 (January 2023)