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Literature summary for 6.3.2.5 extracted from
- Molecular Characterization of the 4'-Phosphopantothenoylcysteine Synthetase Domain of Bacterial Dfp Flavoproteins (2002), J. Biol. Chem., 277, 36137-36145.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A275V | unable to form dimers | Escherichia coli |
| D203N | unable to form dimers | Escherichia coli |
| K289Q | complete loss of enzymic activity | Escherichia coli |
| N210D | complete loss of enzymic activity, but intermediate 4-phosphopanthotenoyl-CMP is formed | Escherichia coli |
| T194V | unable to form dimers | Escherichia coli |
| T198V | unable to form dimers | Escherichia coli |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 26100 | - |
2 * 26100, SDS-PAGE | Escherichia coli |
| 42000 | - |
gel filtration | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-[(R)-4'-phosphopantothenoyl]-L-cysteine | mechanism | Escherichia coli |
aSubunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 26100, SDS-PAGE | Escherichia coli |
| More | enzymic activity lies within the C-terminal domain of Dfp protein | Escherichia coli |
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