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Literature summary for 6.3.2.35 extracted from

  • Lebreton, F.; Depardieu, F.; Bourdon, N.; Fines-Guyon, M.; Berger, P.; Camiade, S.; Leclercq, R.; Courvalin, P.; Cattoir, V.
    D-Ala-d-Ser VanN-type transferable vancomycin resistance in Enterococcus faecium (2011), Antimicrob. Agents Chemother., 55, 4606-4612.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.35

Cloned(Commentary)

Cloned (Comment) Organism
vanL, chromosomal localization, belongs to the vanN operon, genetic organization, DNA and amino acid sequence determination and analysis, sequence comparisons with VanN-type proteins, phylogenetic analysis Enterococcus faecium

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Enterococcus faecium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-alanine + D-serine + ATP Enterococcus faecium
-
 D-alanyl-D-serine + ADP + phosphate
-
 ?
D-alanine + D-serine + ATP Enterococcus faecium UCN71
-
 D-alanyl-D-serine + ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Enterococcus faecium
-
 isolated from a blood culture
-
Enterococcus faecium UCN71
-
 isolated from a blood culture
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-alanine + D-serine + ATP
-
 Enterococcus faecium D-alanyl-D-serine + ADP + phosphate
-
 ?
D-alanine + D-serine + ATP
-
 Enterococcus faecium UCN71 D-alanyl-D-serine + ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
D-alanine:D-serine ligase
-
 Enterococcus faecium
VanL
-
 Enterococcus faecium

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Enterococcus faecium

General Information

General Information Comment Organism
physiological function the enzyme VanL belongs to the vancomycin resistance ligases Enterococcus faecium