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Literature summary for 6.3.2.3 extracted from

  • Cameron, J.C.; Pakrasi, H.B.
    Essential role of glutathione in acclimation to environmental and redox perturbations in the cyanobacterium Synechocystis sp. PCC 6803 (2010), Plant Physiol., 154, 1672-1685.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Synechocystis sp. P73493
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General Information

General Information Comment Organism
physiological function isolation of fully segregated gshB deletion mutants. The mutant strain lacks reduced glutathione but instead accumulates the precursor compound gamma-glutamylcysteine. The deletion strain grows slower than the wild-type strain under favorable conditions and exhibits extremely reduced growth or death when subjected to conditions promoting oxidative stress. After subjecting the strains to multiple environmental and redox perturbations, we found that conditions promoting growth stimulate glutathione biosynthesis. Cellular GSH and gamma-glutamylcysteine content decline following exposure to dark and blue light and during photoheterotrophic growth. A rapid depletion of GSH and gamma-glutamylcysteine is observed in the wild type and the mutant strain, when cells are starved for nitrate or sulfate Synechocystis sp.