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Literature summary for 6.3.2.3 extracted from

  • Nishiya, T.; Mori, K.; Hattori, C.; Kai, K.; Kataoka, H.; Masubuchi, N.; Jindo, T.; Manabe, S.
    The crucial protective role of glutathione against tienilic acid hepatotoxicity in rats (2008), Toxicol. Appl. Pharmacol., 232, 280-291.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information tienilic acid induces the glutathione synthetase and all enzymes of the glutathione biosynthesis pathway, oxidative stress response, and phase II drug metabolism as do oxidative and/or electrophilic stresses, e.g. caused by tienilic acid, regulatory effects, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + gamma-L-glutamyl-L-cysteine + glycine Rattus norvegicus the enzyme catalyzes the last step in glutathione biosynthesis ADP + phosphate + glutathione
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P46413 Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver expression level in presence or absence of tienilic acid, overview Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + gamma-L-glutamyl-L-cysteine + glycine
-
Rattus norvegicus ADP + phosphate + glutathione
-
?
ATP + gamma-L-glutamyl-L-cysteine + glycine the enzyme catalyzes the last step in glutathione biosynthesis Rattus norvegicus ADP + phosphate + glutathione
-
?

Synonyms

Synonyms Comment Organism
Glutathione synthetase
-
Rattus norvegicus
GSS
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus