Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | tienilic acid induces the glutathione synthetase and all enzymes of the glutathione biosynthesis pathway, oxidative stress response, and phase II drug metabolism as do oxidative and/or electrophilic stresses, e.g. caused by tienilic acid, regulatory effects, overview | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + gamma-L-glutamyl-L-cysteine + glycine | Rattus norvegicus | the enzyme catalyzes the last step in glutathione biosynthesis | ADP + phosphate + glutathione | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P46413 | Sprague-Dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | expression level in presence or absence of tienilic acid, overview | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + gamma-L-glutamyl-L-cysteine + glycine | - |
Rattus norvegicus | ADP + phosphate + glutathione | - |
? | |
ATP + gamma-L-glutamyl-L-cysteine + glycine | the enzyme catalyzes the last step in glutathione biosynthesis | Rattus norvegicus | ADP + phosphate + glutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Glutathione synthetase | - |
Rattus norvegicus |
GSS | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |