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Literature summary for 6.3.2.3 extracted from

  • Ren, J.; Privratsky, J.R.; Yang, X.; Dong, F.; Carlson, E.C.
    Metallothionein alleviates glutathione depletion-induced oxidative cardiomyopathy in murine hearts (2008), Crit. Care Med., 36, 2106-2116.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
buthionine sulfoximine reduces the GSH level and the GSH/GSSG ratio without altering GSSG levels in hearts, livers, and kidneys Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus glutathione depletion is critical in cardiac dysfunction, antioxidant therapy shows positive effects on the redox state and in the disease, e.g. in metallothionein overexpressing transgenic mice or by application of buthionine sulfoximine, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
heart
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 Mus musculus
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kidney
-
 Mus musculus
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liver
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information glutathione depletion is critical in cardiac dysfunction, antioxidant therapy shows positive effects on the redox state and in the disease, e.g. in metallothionein overexpressing transgenic mice or by application of buthionine sulfoximine, overview Mus musculus ?
-
 ?