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Literature summary for 6.3.2.26 extracted from

  • Fernandez-Aguado, M.; Teijeira, F.; Martin, J.F.; Ullan, R.V.
    A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum (2013), Appl. Microbiol. Biotechnol., 97, 795-808.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene pcbAB Penicillium chrysogenum

Inhibitors

Inhibitors Comment Organism Structure
additional information PenV i.e. Pc22g22150 protein, located in the vacuolar membrane, affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum, overview Penicillium chrysogenum

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Penicillium chrysogenum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O Penicillium chrysogenum
-
3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
-
?
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O Penicillium chrysogenum Wisconsin 54-1255
-
3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
-
?

Organism

Organism UniProt Comment Textmining
Penicillium chrysogenum B6HLU1 a low penicillin production strain, gene pcbAB
-
Penicillium chrysogenum Wisconsin 54-1255 B6HLU1 a low penicillin production strain, gene pcbAB
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O
-
Penicillium chrysogenum 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
-
?
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O
-
Penicillium chrysogenum Wisconsin 54-1255 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
-
?

Synonyms

Synonyms Comment Organism
ACV synthetase
-
Penicillium chrysogenum
delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine synthetase)
-
Penicillium chrysogenum

Cofactor

Cofactor Comment Organism Structure
ATP
-
Penicillium chrysogenum

General Information

General Information Comment Organism
malfunction RNAi-mediated silencing of penV gene, encoding protein Pc22g22150, UniProt-ID B6HTR9, provokes a drastic reduction of the production of the delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine) and isopenicillin N intermediates and the final product of the pathway Penicillium chrysogenum
physiological function the enzyme catalyzes the non-ribosomal activation and condensation of the three constituent amino acids to form the tripeptide N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine, i.e. ACV Penicillium chrysogenum