Cloned (Comment) | Organism |
---|---|
gene pcbAB | Penicillium chrysogenum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | PenV i.e. Pc22g22150 protein, located in the vacuolar membrane, affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum, overview | Penicillium chrysogenum |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Penicillium chrysogenum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O | Penicillium chrysogenum | - |
3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine | - |
? | |
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O | Penicillium chrysogenum Wisconsin 54-1255 | - |
3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium chrysogenum | B6HLU1 | a low penicillin production strain, gene pcbAB | - |
Penicillium chrysogenum Wisconsin 54-1255 | B6HLU1 | a low penicillin production strain, gene pcbAB | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O | - |
Penicillium chrysogenum | 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine | - |
? | |
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O | - |
Penicillium chrysogenum Wisconsin 54-1255 | 3 AMP + 3 diphosphate + N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACV synthetase | - |
Penicillium chrysogenum |
delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine synthetase) | - |
Penicillium chrysogenum |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Penicillium chrysogenum |
General Information | Comment | Organism |
---|---|---|
malfunction | RNAi-mediated silencing of penV gene, encoding protein Pc22g22150, UniProt-ID B6HTR9, provokes a drastic reduction of the production of the delta-(L-alpha-aminoadipyl-L-cysteinyl-D-valine) and isopenicillin N intermediates and the final product of the pathway | Penicillium chrysogenum |
physiological function | the enzyme catalyzes the non-ribosomal activation and condensation of the three constituent amino acids to form the tripeptide N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine, i.e. ACV | Penicillium chrysogenum |