Literature summary for 6.3.2.26 extracted from

Zhang, J.; Demain, A.L.
Regulation of ACV synthetase activity in the beta-lactam biosynthetic pathway by carbon sources and their metabolites (1992), Arch. Microbiol., 158, 364-369.

No PubMed abstract available

Search for more literature for 6.3.2.26

Inhibitors

Inhibitors	Comment	Organism	Structure
D-glucose	crude extract is inhibited due to deprivation of ATP via sugar metabolism	Acremonium chrysogenum
glyceraldehyde	-	Acremonium chrysogenum
glyceraldehyde	-	Streptomyces clavuligerus
glyceraldehyde-3-phosphate	reacts with L-cysteinee	Acremonium chrysogenum
glyceraldehyde-3-phosphate	reacts with L-cysteinee	Streptomyces clavuligerus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Acremonium chrysogenum
Mg2+	-	Streptomyces clavuligerus

Organism

Organism	UniProt	Comment	Textmining
Acremonium chrysogenum	-	-	-
Streptomyces clavuligerus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Acremonium chrysogenum	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?
L-2-aminoadipate + L-cysteine + L-valine + ATP	-	Streptomyces clavuligerus	N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + AMP + diphosphate	-	?

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Acremonium chrysogenum
ATP	-	Streptomyces clavuligerus

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Release 2023.1 (January 2023)