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Literature summary for 6.3.2.2 extracted from

  • Malki, L.; Yanku, M.; Borovok, I.; Cohen, G.; Mevarech, M.; Aharonowitz, Y.
    Identification and characterization of gshA, a gene encoding the glutamate-cysteine ligase in the halophilic archaeon Haloferax volcanii (2009), J. Bacteriol., 191, 5196-5204.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Haloferax volcanii D4GZN2
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Synonyms

Synonyms Comment Organism
GshA
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Haloferax volcanii

Expression

Organism Comment Expression
Haloferax volcanii GshA gene when expressed in an Escherichia coli strain lacking functional GshA is able to restore synthesis of glutathione additional information

General Information

General Information Comment Organism
physiological function in a strain lacking GshA activity, diamide, a thiol-specific oxidant, significantly inhibits the growth of cells in comparison to those of the wild type. In contrast, 1.0 mM paraquat, 0.1 mM t-butyl hydroperoxide, 0.5 mM hydrogen peroxide, and 0.01 mM menadione have a much less pronounced effect on growth Haloferax volcanii