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Literature summary for 6.3.2.2 extracted from

  • Kaufmann, Y.; Todorova, V.K.; Luo, S.; Klimberg, V.S.
    Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model (2008), Nutr. Cancer, 60, 518-525.
    View publication on PubMed
Search for more literature for 6.3.2.2

Activating Compound

Activating Compound Comment Organism Structure
L-glutamine enhanced enzyme activity in jejunal mucosa Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
L-glutamine inhibition of enzyme activity in tumor tissue Rattus norvegicus
additional information 7,12-dimethylbenz[a]anthracene does not affect GCS enzyme activity in gut tissue Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Rattus norvegicus
-
 ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
additional information Rattus norvegicus tumor development in gut tissue does not affect GCS enzyme activity ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 female Sprague-Dawley rats
-
Rattus norvegicus P19468 Sprague-Dawley rats, female
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
 Rattus norvegicus
-
jejunal mucosa
-
 Rattus norvegicus
-
jejunum mucosa Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 0.13 microg phosphate/mg protein, measured in tumor tissue after treatment with dietary glutamine Rattus norvegicus
additional information
-
 0.2 microg phosphate/mg protein, measured in tumor tissue Rattus norvegicus
additional information
-
 about 0.35 mmicrog phosphate/mg protein, measured in jejunal mucosa in normal rats and DMBA-treated rats with and without tumors Rattus norvegicus
additional information
-
 about 0.43 microg phosphate/mg protein, measured in jejunal mucosa after treatment with dietary glutamine in normal rats and in DMBA-treated rats with and without tumor Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine
-
 Rattus norvegicus ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
ATP + L-glutamate + L-cysteine assay at pH 8 Rattus norvegicus ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
additional information tumor development in gut tissue does not affect GCS enzyme activity Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
gamma-Glutamylcysteine synthetase
-
 Rattus norvegicus
GCS
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus