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Literature summary for 6.3.2.2 extracted from

  • Pereda, J.; Escobar, J.; Sandoval, J.; Rodriguez, J.L.; Sabater, L.; Pallardo, F.V.; Torres, L.; Franco, L.; Vina, J.; Lopez-Rodas, G.; Sastre, J.
    Glutamate cysteine ligase up-regulation fails in necrotizing pancreatitis (2008), Free Radic. Biol. Med., 44, 1599-1609.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information GCLC expression is 3fold up-regulated 1 h after induction of edematous pancreatitis Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
genes GCLC and GCLM, expression analysis of the genes encoding both C and M subunits of GCL Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Rattus norvegicus mechanisms in regulation of GCLC and GCLM expression, overview ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?
additional information Rattus norvegicus induced acute edematous pancreatitis is characterized by marked glutathione depletion in the pancreas, and a rapid restoration of GSH levels involving the enzyme, overview ?
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male Wistar rats, genes GCLC and GCLM
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas
-
Rattus norvegicus
-
pancreatic acinar cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine
-
Rattus norvegicus ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?
ATP + L-glutamate + L-cysteine mechanisms in regulation of GCLC and GCLM expression, overview Rattus norvegicus ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?
additional information induced acute edematous pancreatitis is characterized by marked glutathione depletion in the pancreas, and a rapid restoration of GSH levels involving the enzyme, overview Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
GCL
-
Rattus norvegicus
glutamate cysteine ligase
-
Rattus norvegicus