Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | GCLC expression is 3fold up-regulated 1 h after induction of edematous pancreatitis | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
genes GCLC and GCLM, expression analysis of the genes encoding both C and M subunits of GCL | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | Rattus norvegicus | mechanisms in regulation of GCLC and GCLM expression, overview | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | Rattus norvegicus | induced acute edematous pancreatitis is characterized by marked glutathione depletion in the pancreas, and a rapid restoration of GSH levels involving the enzyme, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male Wistar rats, genes GCLC and GCLM | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Rattus norvegicus | - |
pancreatic acinar cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | - |
Rattus norvegicus | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
ATP + L-glutamate + L-cysteine | mechanisms in regulation of GCLC and GCLM expression, overview | Rattus norvegicus | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | induced acute edematous pancreatitis is characterized by marked glutathione depletion in the pancreas, and a rapid restoration of GSH levels involving the enzyme, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCL | - |
Rattus norvegicus |
glutamate cysteine ligase | - |
Rattus norvegicus |