Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 6.3.2.2 extracted from

  • Sunagawa, S.; Choi, J.; Forman, H.J.; Medina, M.
    Hyperthermic stress-induced increase in the expression of glutamate-cysteine ligase and glutathione levels in the symbiotic sea anemone Aiptasia pallida (2008), Comp. Biochem. Physiol. B, 151, 133-138.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.2.2

Activating Compound

Activating Compound Comment Organism Structure
additional information both GCLC gene expression and total GSH levels increase 4 and 1.5fold, respectively, in response to hyperthermal stress, overview Exaiptasia diaphana

Cloned(Commentary)

Cloned (Comment) Organism
gene gclC encoding the catalytic subunit, DNA and amino acid sequence determination and analysis, quantitative expression analysis Exaiptasia diaphana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Exaiptasia diaphana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Exaiptasia diaphana rate-limiting step in glutathione biosynthesis ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
additional information Exaiptasia diaphana hyperthermal stress triggers adaptive increases in intracellular GSH biosynthesis in cnidarians as a protective response to oxidative/nitrosative stress, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Exaiptasia diaphana B2ZG39 symbiotic sea anemone, genes gclC and gclM encoding the catalytic and the modifier subunits of the enzyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine
-
 Exaiptasia diaphana ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
ATP + L-glutamate + L-cysteine rate-limiting step in glutathione biosynthesis Exaiptasia diaphana ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
 ?
additional information hyperthermal stress triggers adaptive increases in intracellular GSH biosynthesis in cnidarians as a protective response to oxidative/nitrosative stress, overview Exaiptasia diaphana ?
-
 ?

Synonyms

Synonyms Comment Organism
GCL
-
 Exaiptasia diaphana

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Exaiptasia diaphana