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Literature summary for 6.3.2.2 extracted from

  • Bea, F.; Hudson, F.N.; Neff-Laford, H.; White, C.C.; Kavanagh, T.J.; Kreuzer, J.; Preusch, M.R.; Blessing, E.; Katus, H.A.; Rosenfeld, M.E.
    Homocysteine stimulates antioxidant response element-mediated expression of glutamate-cysteine ligase in mouse macrophages (2008), Atherosclerosis, 203, 105-111.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information induction of Gclc by homocysteine, ARE4 plays a direct role in mediating the induction, Nrf2 signalling is critical in homocysteine-induced activation of ARE4, overview Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
genes gclC and gclM, DNA and amino acid sequence determination and analysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus ARE-driven gene expression of Gclc via a MEK/Nrf2 pathway can help to protect macrophages from oxidative stress due to hyperhomocysteinemia ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 genes gclC and gclM
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Source Tissue

Source Tissue Comment Organism Textmining
macrophage
-
 Mus musculus
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RAW-264.7 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ARE-driven gene expression of Gclc via a MEK/Nrf2 pathway can help to protect macrophages from oxidative stress due to hyperhomocysteinemia Mus musculus ?
-
 ?

Subunits

Subunits Comment Organism
dimer heterodimer consisting of catalytic and modifier subunits GCLC and GCLM Mus musculus

Synonyms

Synonyms Comment Organism
GCL
-
 Mus musculus
glutamate cysteine ligase
-
 Mus musculus