Cloned (Comment) | Organism |
---|---|
genes gclC and gclM, genotyping in healthy individuals and in schizophrenia patients, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | Homo sapiens | GCL is the key glutathione-synthesizing enzyme | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | Homo sapiens | the modifier subunit GCLM is not correlated with methamphetamine-use disorder or schizophrenia in the Japanese population, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
Japanese individuals and patients with methamphetamine dependence and induced psychosis, genes gclC and gclM encoding the catalytic and the modifier subunit of the enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-glutamate + L-cysteine | - |
Homo sapiens | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
ATP + L-glutamate + L-cysteine | GCL is the key glutathione-synthesizing enzyme | Homo sapiens | ADP + phosphate + gamma-L-glutamyl-L-cysteine | - |
? | |
additional information | the modifier subunit GCLM is not correlated with methamphetamine-use disorder or schizophrenia in the Japanese population, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | the enzyme consists of a catalytic subunit GCLC and a modifier subunit GCLM | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |