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Literature summary for 6.3.2.2 extracted from

  • Benassi, B.; Zupi, G.; Biroccio, A.
    gamma-Glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells (2007), Mol. Pharmacol., 72, 1015-1023.
    View publication on PubMed

Application

Application Comment Organism
medicine gamma-GCS gene is the downstream target of c-Myc oncoprotein, driving the response to ROS-inducing drugs. gamma-GCS impairment might specifically sensitize high c-Myc tumor cells to chemotherapy Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
generation of C57Bl/6 mice that conditionally overexpress glutamate-cysteine ligase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
melanoma cell gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells Homo sapiens
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