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Literature summary for 6.3.2.2 extracted from

  • Hansen, J.M.; Lee, E.; Harris, C.
    Spatial activities and induction of glutamate-cysteine ligase (GCL) in the postimplantation rat embryo and visceral yolk sac (2004), Toxicol. Sci., 81, 371-378.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
cysteine enzyme from embryo homogenate and from visceral yolk sac homogenate Rattus norvegicus
0.75
-
glutamate enzyme from embryo homogenate Rattus norvegicus
1.38
-
glutamate enzyme from visceral yolk sac homogenate Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + L-cysteine Rattus norvegicus rate-limiting enzyme in GSH synthesis ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo basal expression of glutamate-cysteine ligase catalytic subunit and regulatory subunit is 59fold and 25fold higher in visceral yolk sac, respectively, compared to the embryo Rattus norvegicus
-
yolk sac visceral Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + L-cysteine
-
Rattus norvegicus ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?
ATP + L-glutamate + L-cysteine rate-limiting enzyme in GSH synthesis Rattus norvegicus ADP + phosphate + gamma-L-glutamyl-L-cysteine
-
?