Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-Cys | Mus musculus | first and rate-limiting step in glutathione biosynthesis | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain cortex | - |
Mus musculus | - |
cerebellum | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
additional information | correlating regional-specific expression and activity pattern, levels of heavy and light subunit are similar, distribution in brain | Mus musculus | - |
neostriatum | lower levels | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-Glu + L-2-aminobutyrate | - |
Mus musculus | ADP + phosphate + L-Glu-2-aminobutyrate | - |
? | |
ATP + L-Glu + L-Cys | - |
Mus musculus | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? | |
ATP + L-Glu + L-Cys | first and rate-limiting step in glutathione biosynthesis | Mus musculus | ADP + phosphate + gamma-L-Glu-L-Cys | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the dimeric enzyme is composed of a heavy, catalytic subunit and a light, regulatory subunit | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
gamma-Glutamylcysteine synthetase | - |
Mus musculus |
GCS | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |