Any feedback?
Literature summary for 6.3.2.17 extracted from
- Synthesis of L-2-(N-pteroylamino)-3-(N-phosphonoacetyl)aminopropanoic acid as an analogue of the putative phosphorylated intermediate in the gamma-glutamation of folic acid by folylpolyglutamate synthetase (1999), Pteridines, 10, 39-46.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-(N-phosphonoacetyl)amino-2-L-(N-pteroylamino)propanoic acid | slight inhibition at 0.1 mM | Mus musculus |  |
| 3-N-(methoxyphosphono)acetylamino-2-L-(N-pteroylamino)propanoic acid | slight inhibition at 0.1 mM | Mus musculus | |
| 4-amino-4-deoxypteroyl-L-ornithine | - |
Mus musculus | |
| Nalpha-(4-amino-4-deoxy-5,8-diazapteroyl)-L-ornithine | - |
Mus musculus | |
| Nalpha-(4-amino-4-deoxy-5,chloropteroyl)-L-ornithine | - |
Sus scrofa | |
| Nalpha-(4-amino-4-deoxy-8-deazapteroyl)-L-ornithine | - |
Mus musculus | |
| Nalpha-(4-amino-4-deoxy-N10-methylpteroyl)-Nepsilon-(phosphonoacetyl)-L-lysine | slight inhibition at 0.1 mM | Mus musculus | |
| Nalpha-(5,8-dideaza-5-chloropteroyl)-L-ornithine | - |
Sus scrofa | |
| Nalpha-(5,8-dideazapteroyl)-L-ornithine | - |
Mus musculus | |
| Nalpha-pteroyl-L-ornithine | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.14 | - |
N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)glutamic acid | - |
Mus musculus | |
| 0.14 | - |
N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)glutamic acid | - |
Sus scrofa | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine | ? | - |
? | |
| additional information | Sus scrofa | the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
mouse | - |
| Sus scrofa | - |
pig | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
| liver | - |
Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + 3-(N-phosphonoacetyl)amino-2-L-(N-pteroylamino)propanoic acid + L-glutamate | much less effective than folic acid | Mus musculus | ADP + 3-(N-phosphonoacetyl)amino-2-L-(N-pteroylamino)propanoyl-Glu + phosphate | - |
? | |
| ATP + 3-N-(methoxyphosphono)acetylamino-2-L-(N-pteroylamino)propanoic acid + L-glutamate | much less effective than folic acid | Mus musculus | ADP + 3-N-(methoxyphosphono)acetylamino-2-L-(N-pteroylamino)propanoyl-Glu + phosphate | - |
? | |
| ATP + 4-amino-4-deoxypteroyl-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
| ATP + N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)glutamic acid + L-glutamate | folic acid | Mus musculus | ADP + phosphate + N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)-Glu2 | - |
? | |
| ATP + N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)glutamic acid + L-glutamate | folic acid | Sus scrofa | ADP + phosphate + N-(p(((2-amino-4-hydroxy-6-pteridinyl)methyl)-amino)benzoyl)-Glu2 | - |
? | |
| ATP + Nalpha-(4-amino-4-deoxy-5,8-diazapteroyl)-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
| ATP + Nalpha-(4-amino-4-deoxy-5,chloropteroyl)-L-ornithine + L-glutamate | - |
Sus scrofa | ? | - |
? | |
| ATP + Nalpha-(4-amino-4-deoxy-8-deazapteroyl)-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
| ATP + Nalpha-(4-amino-4-deoxy-N10-methylpteroyl)-Nepsilon-(phosphonoacetyl)-L-lysine + L-glutamate | much less effective than folic acid | Mus musculus | ? | - |
? | |
| ATP + Nalpha-(5,8-dideaza-5-chloropteroyl)-L-ornithine + L-glutamate | - |
Sus scrofa | ? | - |
? | |
| ATP + Nalpha-(5,8-dideazapteroyl)-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
| ATP + Nalpha-pteroyl-L-ornithine + L-glutamate | - |
Mus musculus | ? | - |
? | |
| additional information | the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine | Mus musculus | ? | - |
? | |
| additional information | the enzyme catalyzes the consecutive addition of one or more L-glutamyl moieties to the gamma-carboxyl group in natural folates and glutamate-containing antifolates. Cells deficient in this enzyme are auxothrophic for thymidine and a purine | Sus scrofa | ? | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000017 | - |
Nalpha-(4-amino-4-deoxy-5,chloropteroyl)-L-ornithine | - |
Sus scrofa | |
| 0.0000083 | - |
Nalpha-(5,8-dideaza-5-chloropteroyl)-L-ornithine | - |
Sus scrofa | |
| 0.000018 | - |
Nalpha-(4-amino-4-deoxy-8-deazapteroyl)-L-ornithine | - |
Mus musculus | |
| 0.000072 | - |
Nalpha-(4-amino-4-deoxy-5,8-diazapteroyl)-L-ornithine | - |
Mus musculus | |
| 0.00015 | - |
4-amino-4-deoxypteroyl-L-ornithine | - |
Mus musculus | |
| 0.00035 | - |
Nalpha-(5,8-dideazapteroyl)-L-ornithine | - |
Mus musculus | |
| 0.0035 | - |
Nalpha-pteroyl-L-ornithine | - |
Mus musculus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
