Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3,3-difluoroglutamate | the incorporation of 3,3-difluoroglutamate promotes the further synthesis of polyglutamates | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.41 | - |
3,3-difluoroglutamate | reaction with methotrexate + ATP | Rattus norvegicus | |
0.74 | - |
Glu | reaction with methotrexate + ATP | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + methotrexate + 3,3-difluoroglutamate | - |
Rattus norvegicus | ADP + phosphate + methotrexyl-3,3-difluoroglutamate | - |
? | |
ATP + methotrexate + Glu | - |
Rattus norvegicus | ADP + phosphate + methotrexyl-Glu | - |
? |