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Literature summary for 6.3.2.17 extracted from

  • McGuire, J.J.; Haile, W.H.; Bey, P.; Coward, J.K.
    DL-3,3-Difluoroglutamate: an enhancer of folylpolyglutamate elongation (1990), J. Biol. Chem., 265, 14073-14079.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
3,3-difluoroglutamate the incorporation of 3,3-difluoroglutamate promotes the further synthesis of polyglutamates Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.41
-
3,3-difluoroglutamate reaction with methotrexate + ATP Rattus norvegicus
0.74
-
Glu reaction with methotrexate + ATP Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + methotrexate + 3,3-difluoroglutamate
-
Rattus norvegicus ADP + phosphate + methotrexyl-3,3-difluoroglutamate
-
?
ATP + methotrexate + Glu
-
Rattus norvegicus ADP + phosphate + methotrexyl-Glu
-
?