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Literature summary for 6.3.2.12 extracted from

  • Ho, R.I.; Corman, L.; Ho, J.; Nair, M.G.
    A simple radioassay for dihydrofolate synthetase activity in Escherichia coli and its applicationto an inhibition study of new pteroate analogs (1976), Anal. Biochem., 73, 493-500.
    View publication on PubMed
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Application

Application Comment Organism
analysis a simple radioassay for dihydrofolate synthetase activity and its application to an inhibition study of new pteroate analogs Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Dihydro-10-thiopteroic acid
-
 Escherichia coli
dihydrofolic acid
-
 Escherichia coli
dihydrohomopteroic acid
-
 Escherichia coli
Dihydroisopteroic acid
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Neisseria meningitidis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 7,8-dihydropteroate + L-Glu
-
 Escherichia coli ADP + phosphate + 7,8-dihydrofolate
-
 ?
ATP + 7,8-dihydropteroate + L-Glu
-
 Neisseria meningitidis ADP + phosphate + 7,8-dihydrofolate
-
 ?