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Literature summary for 6.3.1.4 extracted from

  • Gjymishka, A.; Su, N.; Kilberg, M.S.
    Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway (2008), Biochem. J., 417, 695-703.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the unfolded protein response, UPR, pathway is comprised of three signaling cascades, mediated by the ER stress sensor proteins PERK, IRE1, and ATF6, and PERK is responsible for activation of the ASNS, while the IRE1/XBP1 and ATF6 branches of the UPR do not participate in the induction of ASNS transcription, overview Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
quantitative enzyme expression analysis in Hep-G2 cells in absence or presence of UPR blockers and activators, transcription factor recruitment to the ASNS promoter during the UPR, transcriptional activation of UPR target genes is mediated by three signaling cascades PERK/eIF2alpha/ATF4, ATF6, and IRE1/XBP1, UPR activation does not trigger increased recruitment of Mediator subunits to the ASNS promoter, the IRE1/XBP1 and ATF6 branches of the UPR do not participate in the induction of ASNS transcription, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-aspartate + NH3 Homo sapiens
-
ADP + phosphate + L-asparagine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-aspartate + NH3
-
Homo sapiens ADP + phosphate + L-asparagine
-
?

Synonyms

Synonyms Comment Organism
ASNS
-
Homo sapiens
Asparagine synthetase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens