Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the unfolded protein response, UPR, pathway is comprised of three signaling cascades, mediated by the ER stress sensor proteins PERK, IRE1, and ATF6, and PERK is responsible for activation of the ASNS, while the IRE1/XBP1 and ATF6 branches of the UPR do not participate in the induction of ASNS transcription, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
quantitative enzyme expression analysis in Hep-G2 cells in absence or presence of UPR blockers and activators, transcription factor recruitment to the ASNS promoter during the UPR, transcriptional activation of UPR target genes is mediated by three signaling cascades PERK/eIF2alpha/ATF4, ATF6, and IRE1/XBP1, UPR activation does not trigger increased recruitment of Mediator subunits to the ASNS promoter, the IRE1/XBP1 and ATF6 branches of the UPR do not participate in the induction of ASNS transcription, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-aspartate + NH3 | Homo sapiens | - |
ADP + phosphate + L-asparagine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-aspartate + NH3 | - |
Homo sapiens | ADP + phosphate + L-asparagine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ASNS | - |
Homo sapiens |
Asparagine synthetase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |