Literature summary for 6.3.1.2 extracted from

Hammer, J.; Alvestad, S.; Osen, K.K.; Skare, ?.; Sonnewald, U.; Ottersen, O.P.
Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy (2008), Glia, 56, 856-868.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-glutamate + NH3	Rattus norvegicus	the enzyme is involved in development of mesial temporal lobe epilepsy, MTLE	ADP + phosphate + L-glutamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Sprague Dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Rattus norvegicus	-
brain	-	Rattus norvegicus	-
glial cell	quantitative analysis of enzyme content at different epileptic stages compared to control rats, overview	Rattus norvegicus	-
hippocampus	quantitative analysis of enzyme content at different epileptic stages compared to control rats, overview	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-glutamate + NH3	-	Rattus norvegicus	ADP + phosphate + L-glutamine	-	?
ATP + L-glutamate + NH3	the enzyme is involved in development of mesial temporal lobe epilepsy, MTLE	Rattus norvegicus	ADP + phosphate + L-glutamine	-	?

Synonyms

Synonyms	Comment	Organism
Glutamine synthetase	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Rattus norvegicus

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Release 2023.1 (January 2023)