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Literature summary for 6.3.1.2 extracted from

  • Eid, T.; Ghosh, A.; Wang, Y.; Beckstroem, H.; Zaveri, H.P.; Lee, T.S.; Lai, J.C.; Malthankar-Phatak, G.H.; de Lanerolle, N.C.
    Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats (2008), Brain, 131, 2061-2070.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.3.1.2

Application

Application Comment Organism
medicine restoration of glutamine synthetase may represent an approach to therapeutic intervention in mesial temporal lobe epilepsy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
methionine sulfoximine
-
 Homo sapiens
methionine sulfoximine irreversible inhibition up to 97% in vivo after longterm treatment over 3 h by Intracranial infusion Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + NH3 Homo sapiens
-
 ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3 Rattus norvegicus
-
 ADP + phosphate + L-glutamine
-
 ?
additional information Rattus norvegicus deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, overview ?
-
 ?
additional information Homo sapiens extracellular glutamate in the hippocampus causes recurrent seizures and is involved in medically intractable mesial temporal lobe epilepsy, MTLE, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 male Sprague Dawley rats
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
brain
-
 Rattus norvegicus
-
hippocampus
-
 Homo sapiens
-
hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + NH3
-
 Homo sapiens ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3
-
 Rattus norvegicus ADP + phosphate + L-glutamine
-
 ?
additional information deficiency in hippocampal glutamine synthetase causes recurrent seizures, even in the absence of classical mesial temporal sclerosis, overview Rattus norvegicus ?
-
 ?
additional information extracellular glutamate in the hippocampus causes recurrent seizures and is involved in medically intractable mesial temporal lobe epilepsy, MTLE, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Glutamine synthetase
-
 Homo sapiens
Glutamine synthetase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Rattus norvegicus