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Literature summary for 6.3.1.2 extracted from

  • Vermeulen, T.; Goerg, B.; Vogl, T.; Wolf, M.; Varga, G.; Toutain, A.; Paul, R.; Schliess, F.; Haeussinger, D.; Haeberle, J.
    Glutamine synthetase is essential for proliferation of fetal skin fibroblasts (2008), Arch. Biochem. Biophys., 478, 96-102.
    View publication on PubMed
Search for more literature for 6.3.1.2

Cloned(Commentary)

Cloned (Comment) Organism
quantitative expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information enzyme-deficient cells show altered cell proliferation rates compared to the wild-type or enzyme overexpressing cells, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
L-methionine sulfoximine loss of glutamine synthetase activity either inherited or induced through L-methionine sulfoximine leads to an upregulation of the glutamine synthetase protein but not of the glutamine synthetase mRNA and results in a significant drop in the proliferation rate but has no effect on apoptosis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-glutamate + NH3 Homo sapiens glutamine synthetase is essential for proliferation of fetal skin fibroblasts ADP + phosphate + L-glutamine
-
 ?
additional information Homo sapiens loss of glutamine synthetase activity either inherited or induced through L-methionine sulfoximine leads to an upregulation of the glutamine synthetase protein but not of the glutamine synthetase mRNA and results in a significant drop in the proliferation rate but has no effect on apoptosis. Exogenous glutamine does not influence the rate of apoptosis but increases proliferation rates of the fetal but not the mature fibroblasts ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast fetal Homo sapiens
-
skin
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-glutamate + NH3
-
 Homo sapiens ADP + phosphate + L-glutamine
-
 ?
ATP + L-glutamate + NH3 glutamine synthetase is essential for proliferation of fetal skin fibroblasts Homo sapiens ADP + phosphate + L-glutamine
-
 ?
additional information loss of glutamine synthetase activity either inherited or induced through L-methionine sulfoximine leads to an upregulation of the glutamine synthetase protein but not of the glutamine synthetase mRNA and results in a significant drop in the proliferation rate but has no effect on apoptosis. Exogenous glutamine does not influence the rate of apoptosis but increases proliferation rates of the fetal but not the mature fibroblasts Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Glutamine synthetase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens