Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-methionine S-sulfoximine | IC50: 3 mM | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
ADP | pH 7.0 | Mycobacterium tuberculosis | |
8.3 | - |
hydroxylamine | pH 7.0 | Mycobacterium tuberculosis | |
60 | - |
L-Gln | pH 7.0 | Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | Km: 0.025 mM | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mycobacterium tuberculosis | essential enzyme involved in the pathogenicity of Mycobacterium tuberculosis | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant enzyme | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Gln + hydroxylamine + ADP | - |
Mycobacterium tuberculosis | gamma-glutamylhydroxamate + NH4+ + ? | - |
? | |
additional information | essential enzyme involved in the pathogenicity of Mycobacterium tuberculosis | Mycobacterium tuberculosis | ? | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
pH 7.0, 0.002 mM ADP, 0.005 mM arsenate, 0.025 mM Mn2+, 60 mM L-glutamine, 8.3 mM hydroxylamine, stable for at least 3 h | Mycobacterium tuberculosis |
37 | - |
pH 7.0, 0.002 mM ADP, 0.005 mM arsenate, 0.025 mM Mn2+, 60 mM L-glutamine, 8.3 mM hydroxylamine, stable for at least 3 h | Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
3 | - |
IC50: 3 mM | Mycobacterium tuberculosis | L-methionine S-sulfoximine |